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22q11 Deletion Syndrome and Forensic Research: Can We Go There?

Dr. Harris is Assistant Professor, Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA. Address correspondence to: Victoria Harris, MD, MPH, Department of Psychiatry and Behavioral Sciences, University of Washington, Box 356560, 1959 NE Pacific, BB-1644 Health Services Building, Seattle, WA 98155. E-mail: vharris{at}u.washington.edu

Chromosome 22q11 deletion syndrome (22q11DS) encompasses velocardiofacial syndrome (VCFS), DiGeorge syndrome (DGS), and conotruncal anomaly face syndrome (CTAFS). The disorder may represent the interface between genetics and brain-behavior relationships. As there is a strong relationship between the genetic syndrome and schizophrenia, individuals with the disorder are likely to be disproportionately represented in the criminal justice system. The purpose of this article is to review the 22q11DS in the context of forensic research. The existing literature regarding the syndrome and its relationship to schizophrenia is reviewed. A study design is presented to determine the prevalence of the syndrome in correctional facilities compared with expected community prevalence rates. Finally, a brief history of genetic research in correctional facilities is reviewed as a potential model to determine the feasibility of research involving 22q11DS.