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Potential Side Effects of Androgen Deprivation Treatment in Sex Offenders

Dr. Giltay is a psychiatrist and epidemiologist, Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands; Dr. Gooren is an endocrinologist and internist, Department of Endocrinology, Andrology Unit, VU University Medical Center, Amsterdam, The Netherlands. Address correspondence to: Erik J. Giltay, MD, PhD, Department of Psychiatry, Leiden University Medical Center, Postbus 9600, 2300 RC, Leiden, The Netherlands. E-mail: giltay{at}dds.nl

Testosterone is an important hormone involved in sexual arousal, and, indeed, a profound reduction of testosterone levels may be helpful in controlling sexual impulses in sex offenders. Earlier thought of as a sex hormone only, testosterone has been increasingly shown to have manifold actions in the adult male. Normal adult levels of androgens are required for the health of bones, a large number of metabolic functions, mood, erythropoiesis, sebaceous gland activity of the skin, and several other functions. Severe androgen deficiency is associated with pathologies of these biological systems. Androgen deprivation therapy may result in osteoporosis, weight gain with an increased visceral adiposity, impaired glucose tolerance, dyslipidemia, and emotional disturbances. Some of these features combine in the metabolic syndrome that is also frequently associated with the use of psychotropic medication in general. It leads to a moderately increased risk of fractures and diabetes mellitus (by 40%–50%), and a small increased risk of cardiovascular morbidity and depression (by 10%–20%). It should be noted that small proportionate increases in risk may be of modest clinical significance when background risks are very low. Effective and safe management of sex offenders treated with testosterone-deprivation therapy should include careful monitoring of side effects and their prevention and treatment.

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				F. S. Berlin Commentary: Risk/Benefit Ratio of Androgen Deprivation Treatment for Sex Offenders J Am Acad Psychiatry Law, March 1, 2009; 37(1): 59 - 62. [Abstract] [Full Text] [PDF]