Abstract
Diffusion tensor imaging (DTI) has become one of the most popular MRI techniques in brain research, as well as in clinical practice. The number of brain studies with DTI is growing steadily and, over the last decade, has produced more than 700 publications. Diffusion tensor imaging enables visualization and characterization of white matter fascicli in two and three dimensions. Since the introduction of this methodology in 1994, it has been used to study the white matter architecture and integrity of the normal and diseased brains (multiple sclerosis, stroke, aging, dementia, schizophrenia, etc.). Although it provided image contrast that was not available with routine MR techniques, unique information on white matter and 3D visualization of neuronal pathways, many questions were raised regarding the origin of the DTI signal. Diffusion tensor imaging is constantly validated, challenged, and developed in terms of acquisition scheme, image processing, analysis, and interpretation. While DTI offers a powerful tool to study and visualize white matter, it suffers from inherent artifacts and limitations. The partial volume effect and the inability of the model to cope with non-Gaussian diffusion are its two main drawbacks. Nevertheless, when combined with functional brain mapping, DTI provides an efficient tool for comprehensive, noninvasive, functional anatomy mapping of the human brain. This review summarizes the development of DTI in the last decade with respect to the specificity and utility of the technique in radiology and anatomy studies.
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Alexander, D. C., Barker, G. J., & Arridge, S. R. (2002). Detection and modeling of non-Gaussian apparent diffusion coefficient profiles in human brain data. Magnetic Resonance in Medicine, 48, 331–340.
Ardekani, B. A., Nierenberg, J., Hoptman, M. J., Javitt, D. C., & Lim, K. O. (2003). MRI study of white matter diffusion anisotropy in schizophrenia. NeuroReport, 14, 2025–2029.
Assaf, Y., & Basser, P. J. (2005). Composite hindered and restricted model of diffusion (CHARMED) MR imaging of the human brain. NeuroImage, 27, 48–58.
Assaf, Y., & Cohen, Y. (1998). Non-mono-exponential attenuation of water and N-acetyl aspartate signals due to diffusion in brain tissue. Journal of Magnetic Resonance, 131, 69–85.
Assaf, Y., & Cohen, Y. (2000). Assignment of the water slow-diffusing component in the central nervous system using q-space diffusion MRS: implications for fiber tract imaging. Magnetic Resonance in Medicine, 43, 191–199.
Assaf, Y., Ben-Bashat, D., Chapman, J., Peled, S., Biton, I. E., Kafri, M., et al. (2002). High b-value q-space analyzed diffusion-weighted MRI: application to multiple sclerosis. Magnetic Resonance in Medicine, 47, 115–126.
Assaf, Y., Pianka, P., Rothstein, P., Sigal, M., & Hendler, T. (2003). Deviation of fiber tracts in the vicinity of brain lesions: evaluation by diffusion tensor imaging. Israel Journal of Chemistry, 43, 155–163.
Aubourg, P., & Mandel, J. L. (1996). X-linked adrenoleukodystrophy. Annals of the New York Academy of Sciences, 804, 461–476.
Beaulieu, C. (2002). The basis of anisotropic water diffusion in the nervous system—a technical review. NMR in Biomedicine, 15, 435–455.
Bammer, R., Augustin, M., Strasser-Fuchs, S., Seifert, T., Kapeller, P., Stollberger, R., et al. (2000). Magnetic resonance diffusion tensor imaging for characterizing diffuse and focal white matter abnormalities in multiple sclerosis. Magnetic Resonance in Medicine, 44, 583–591.
Basser, P. J. (1995). Inferring microstructural features and the physiological state of tissues from diffusion-weighted images. NMR in Biomedicine, 7–8, 333–344.
Basser, P. J., & Jones, D. K. (2002). Diffusion-tensor MRI: theory, experimental design and data analysis—a technical review. NMR in Biomedicine, 15, 456–467.
Basser, P. J., & Pierpaoli, C. (1996). Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI. Journal of Magnetic Resonance Series B, 111, 209–219.
Basser, P. J., & Pierpaoli, C. (1998). A simplified method to measure the diffusion tensor from seven MR images. Magnetic Resonance in Medicine, 39, 928–934.
Basser, P. J., Mattiello, J., & Le Bihan, D. (1994). MR diffusion tensor spectroscopy and imaging. Biophysical Journal, 66, 259–267.
Basser, P. J., Pajevic, S., Pierpaoli, C., Duda, J., & Aldroubi, A. (2000). In vivo fiber tractography using DT-MRI data. Magnetic Resonance in Medicine, 44, 625–632.
Beaulieu, C., & Allen, P. S. (1994). Determinants of anisotropic water diffusion in nerves. Magnetic Resonance in Medicine, 31, 394–400.
Betz, A. L., Iannotti, F., & Hoff, J. T. (1989). Brain edema: a classification based on blood–brain barrier integrity. Cerebrovascular and Brain Metabolism Reviews, 11, 133–154.
Bozzali, M., Falini, A., Franceschi, M., Cercignani, M., Zuffi, M., Scotti, G., et al. (2002). White matter damage in Alzheimer’s disease assessed in vivo using diffusion tensor magnetic resonance imaging. Journal of Neurology, Neurosurgery and Psychiatry, 72, 742–746.
Callaghan, P. T. (Ed.) (1991). Principles of Nuclear Magnetic Resonance Microscopy. Oxford: Oxford University Press.
Callaghan, P. T., Coy, A., MacGowan, D., Packer, K. J., & Zelaya, F. O. (1991). Diffraction like effects in NMR diffusion studies of fluid in porous solids. Nature, 351, 467–469.
Carano, R. A., Li, F., Irie, K., Helmer, K. G., Silva, M. D., Fisher, M., et al. (2000) Multispectral analysis of the temporal evolution of cerebral ischemia in the rat brain. Journal of Magnetic Resonance Imaging, 12, 842–858.
Catani, M., & Ffytche, D. H. (2005). The rises and falls of disconnection syndromes. Brain, 128, 2224–2239.
Catani, M., Howard, R. J., Pajevic, S., & Jones, D. K. (2002). Virtual in vivo interactive dissection of white matter fasciculi in the human brain. NeuroImage, 17, 77–94.
Ciccarelli, O., Werring, D. J., Wheeler-Kingshott, C. A., Barker, G. J., Parker, G. J., Thompson, A. J., et al. (2001). Investigation of MS normal-appearing brain using diffusion tensor MRI with clinical correlations. Neurology, 56, 926–933.
Clark, C. A., Barrick, T. R., Murphy, M. M., & Bell, B. A. (2003). White matter tracking in patients with space-occupying lesions of the brain: a new technique for neurosurgical planning? NeuroImage, 20, 1601–1608.
Cohen, Y., & Assaf, Y. (2002). High b-value q-space analyzed diffusion-weighted MRS and MRI in neuronal tissues—a technical review. NMR in Biomedicine, 15, 516–542.
Conturo, T. E., Lori, N. F., Cull, T. S., Akbudak, E., Snyder, A. Z., Shimony, J. S., et al. (1999). Tracking neuronal fiber pathways in the living human brain. Proceedings of the National Academy of Sciences of the United States of America, 96, 10422–10427.
Cory, D. G., & Garroway, A. N. (1990). Measurement of translational displacement probabilities by NMR—an indicator of compartmentation. Magnetic Resonance in Medicine, 14, 435–444.
Cruz, Jr, L. C., & Sorensen, A. G. (2005). Diffusion tensor magnetic resonance imaging of brain tumors. Neurosurgery Clinics of North America, 16, 115–134.
Dumas de la Roque, A., Oppenheim, C., Chassoux, F., Rodrigo, S., Beuvon, F., Daumas-Duport, C., et al. (2005). Diffusion tensor imaging of partial intractable epilepsy. European Radiology, 15, 279–285.
Eichler, F. S., Itoh, R., Barker, P. B., Mori, S., Garrett, E. S., van Zijl, P. C., et al. (2002). Proton MR spectroscopic and diffusion tensor brain MR imaging in X-linked adrenoleukodystrophy: initial experience. Radiology, 225, 245–252.
Fellgiebel, A., Muller, M. J., Wille, P., Dellani, P. R., Scheurich, A., Schmidt, L. G., et al. (2005). Color-coded diffusion-tensor-imaging of posterior cingulate fiber tracts in mild cognitive impairment. Neurobiology of Aging, 26, 1193–1198.
Fellgiebel, A., Wille, P., Muller, M. J., Winterer, G., Scheurich, A., Vucurevic, G., et al. (2004). Ultrastructural hippocampal and white matter alterations in mild cognitive impairment: a diffusion tensor imaging study. Dementia and Geriatric Cognitive Disorders, 18, 101–108.
Filippi, M., Cercignani, M., Inglese, M., Horsfield, M. A., & Comi, G. (2001). Diffusion tensor magnetic resonance imaging in multiple sclerosis. Neurology, 56, 304–311.
Green, H. A., Pena, A., Price, C. J., Warburton, E. A., Pickard, J. D., Carpenter, T. A., et al. (2002). Increased anisotropy in acute stroke: a possible explanation. Stroke, 33, 1517–1521.
Griffin, C. M., Chard, D. T., Ciccarelli, O., Kapoor, B., Barker, G. J., Thompson, A. I., et al. (2001). Diffusion tensor imaging in early relapsing-remitting multiple sclerosis. Multiple Sclerosis, 7, 290–297.
Guye, M., Parker, G. J., Symms, M., Boulby, P., Wheeler-Kingshott, C. A., Salek-Haddadi, A., et al. (2003). Combined functional MRI and tracotgraphy to demonstrate the connectivity of the human primary motor cortex in vivo. NeuroImage, 19, 1349–1360
Hendler, T., Pianka, P., Sigal, M., Kafri, M., Ben-Bashat, D., Constantini, S., et al. (2003). Delineating gray and white matter involvement in brain lesions: 3D alignment of fMRI and DTI. Journal of Neurosurgery, 99, 1018–1027.
Horsfield, M. A., Larsson, H. B., Jones, D. K., & Gass, A. (1998). Diffusion magnetic resonance imaging in multiple sclerosis. Journal of Neurology, Neurosurgery and Psychiatry, 64(S1), S80–S84.
Huppi, P. S., Maier, S. E., Peled, S., Zientara, G. P., Barnes, P. D., Jolesz, F. A., et al. (1998). Microstructural development of human newborn cerebral white matter assessed in vivo by diffusion tensor magnetic resonance imaging. Pediatric Research, 44, 584–590.
Ito, R., Melhem, E. R., Mori, S., Eichler, F. S., Raymond, G. V., & Moser, H. W. (2001). Diffusion tensor brain MR imaging in X-linked cerebral adrenoleukodystrophy. Neurology, 56, 544–547.
Ito, U., Ohno, K., Nakamura, R., Suganuma, F., & Inaba, Y. (1979). Brain edema during ischemia and after restoration of blood flow. Measurement of water, sodium, potassium content and plasma protein permeability. Stroke, 10, 542–547.
Jansons, K. M., & Alexander, D. C. (2003). Persistent angular structure: new insights from diffusion MRI data. Dummy version. Information Processing in Medical Imaging, 18, 672–683.
Jensen, J. H., Helpern, J. A., Ramani, A., Lu, H., & Kaczynski, K. (2005). Diffusional kurtosis imaging: the quantification of non-Gaussian water diffusion by means of magnetic resonance imaging. Magnetic Resonance in Medicine, 53, 1432–1440.
Jones, D. K., Lythgoe, D., Horsfield, M. A., Simmons, A., Williams, S. C., & Markus, H. S. (1999). Characterization of white matter damage in ischemic leukoaraiosis with diffusion tensor MRI. Stroke, 30, 393–397.
Jones, D. K., Symms, M. R., Cercignani, M., & Howard, R. J. (2005). The effect of filter size on VBM analyses of DT-MRI data. NeuroImage, 26, 546–554.
Kafri, M., Bova, I., Pianka, P., Aizenstein, O., Hendler, T., Borenstein, N., et al. (2005). Segmented ROI Analysis of DTI in Stroke. Proceedings of the International Society for Magnetic Resonance in Medicine, 12, 1373.
Kanaan, R. A., Kim, J. S., Kaufmann, W. E., Pearlson, G. D., Barker, G. J., & McGuire, P. K. (2005). Diffusion tensor imaging in schizophrenia. Biological Psychiatry, 58, 921–929.
Kealey, S. M., & Provenzale, J. M. (2002). Tensor diffusion imaging in B12 leukoencephalopathy. Journal of Computer Assisted Tomography, 26, 952–955.
Kobari, M., Meyer, J. S., Ichijo, M., & Oravez, W. T. (1990). Leukoaraiosis: correlation of MR and CT findings with blood flow, atrophy, and cognition. American Journal of Neuroradiology, 11, 273–281.
Kubicki, M., McCarley, R., Westin, C. F., Park, H. J., Maier, S., Kikinis, R., et al. (2005). A review of diffusion tensor imaging studies in schizophrenia. Journal of Psychiatric Research, 41, 15–30.
Kumra, S., Ashtari, M., McMeniman, M., Vogel, J., Augustin, R., Becker, D. E., et al. (2004) Reduced frontal white matter integrity in early-onset schizophrenia: a preliminary study. Biological Psychology, 55, 1138–1145.
Le Bihan, D. (Ed.) (1995). Diffusion and Perfusion MRI, 1st Edition. New York: Raven.
Lim, K. O., & Helpern, J. A. (2002). Neuropsychiatric applications of DTI—a review. NMR in Biomedicine, 15, 587–593.
Lu, S., Ahn, D., Johnson, G., Law, M., Zagzag, D., & Grossman, R. I. (2004). Diffusion-tensor MR imaging of intracranial neoplasia and associated peritumoral edema: introduction of the tumor infiltration index. Radiology, 232, 221–228.
Magaro, P. A., & Page, J. (1983). Brain disconnection, schizophrenia, and paranoia. The Journal of Nervous and Mental Disease, 171, 133–140.
Medina, D., Detoledo-Morrell, L., Urresta, F., Gabrieli, J. D., Moseley, M., Fleischman, D., et al. (2005) White matter changes in mild cognitive impairment and AD: A diffusion tensor imaging study. Neurobiology of Aging, 27, 663–672.
Mori, S., Crain, B. J., Chacko, V. P., & van Zijl, P. C. M. (1999). Three dimensional tracking of axonal projections in the brain by magnetic resonance imaging. Annals of Neurology, 45, 265–269.
Mori, S., Wakana, S., Nagae-Poetscher, L. M., & van Zijl, P. C. M. (Eds.) (2005). MRI Atlas of Human White Matter, 1st Edition. Amsterdam: Elsevier.
Moseley, M., Bammer, R., & Illes, J. (2002). Diffusion-tensor imaging of cognitive performance. Brain and Cognition, 50, 396–413.
Moseley, M. E., Cohen, Y., Kucharczyk, J., Mintorovitch, J., Asgari, H. S., Wendland, M. F., et al. (1990). Diffusion-weighted MR imaging of anisotropic water diffusion in cat central-nervous-system. Radiology, 176, 439–445.
Moseley, M. E., Hucharczyk, J., Asgari, H. S., & Norman, D. (1991). Anisotropy in diffusion-weighted MRI. Magnetic Resonance in Medicine, 19, 321–326.
Mukherjee, P., Miller, J. H., Shimony, J. S., Conturo, T. E., Lee, B. C., Almli, C. R., et al. (2001). Normal brain maturation during childhood: developmental trends characterized with diffusion-tensor MR imaging. Radiology, 221, 349–358.
Papadakis, N. G., Martin, K. M., Mustafa, M. H., Wilkinson, I. D., Griffiths, P. D., Huang, C.L., et al. (2002). Study of the effect of CSF suppression on white matter diffusion anisotropy mapping of healthy human brain. Magnetic Resonance in Medicine, 48, 394–398.
Parmar, H., Sitoh, Y. Y., & Yeo, T. T. (2004). Combined magnetic resonance tracotgraphy and functional magnetic resonance imaging in evaluation of brain tumors involving the motor system. Journal of Computer Assisted Tomography, 28, 551–556
Pajevic, S., & Pierpaoli, C. (1999). Color schemes to represent the orientation of anisotropic tissues from diffusion tensor data: application to white matter fiber tract mapping in the human brain. Magnetic Resonance in Medicine, 42, 526–540.
Pasternak, O., Sochen, N., & Assaf, Y. (2004). Separation of white matter fascicles from diffusion MRI using -functional regularization. Proceedings of the International Society for Magnetic Resonance in Medicine, 12, 1227.
Pasternak, O., Sochen, N., & Assaf, Y. (2006). PDE based estimation and regularization of multiple diffusion tensor fields. In J. Weickert & H. Hagen (Eds.), Visualization and image processing of tensor fields. Berlin: Springer.
Papadakis, N. G., Xing, D., Houston, G. C., Smith, J. M., Smith, M. I., James, M. F., et al. (1999). A study of rotationally invariant and symmetric indices of diffusion anisotropy. Magnetic Resonance Imaging, 17, 881–892.
Pierpaoli, C., & Basser, P. J. (1996). Toward a quantitative assessment of diffusion anisotropy. Magnetic Resonance in Medicine, 36, 893–906.
Pierpaoli, C., Jezzard, P., Basser, P. J., Barnett, A., & Di Chiro, G. (1996). Diffusion tensor MR imaging of the human brain. Radiology, 201, 637–648.
Poupon, C., Clark, C. A., Frouin, V., Regis, J., Bloch, I., Le Bihan, D., et al. (2000). Regularization of diffusion-based direction maps for the tracking of brain white matter fascicles. NeuroImage, 12, 184–195.
Price, G., Bagary, M. S., Cercignani, M., Altmann, D. R., & Ron, M. A. (2005). The corpus callosum in first episode schizophrenia: a diffusion tensor imaging study. Journal of Neurology, Neurosurgery and Psychiatry, 76, 585–587.
Sakuma, H., Nomura, Y., Takeda, K., Tagami, T., Nakagawa, T., Tamagawa, Y., et al. (1991). Adult and neuonatal human brain: diffusional anisotropy and myelination with diffusion-weighted MR imaging. Radiology, 180, 229–233.
Salat, D. H., Tuch, D. S., Greve, D. N., van der Kouwe, A. J., Hevelone, N. D., Zaleta, A. K., et al. (2005). Age-related alterations in white matter microstructure measured by diffusion tensor imaging. Neurobiology Aging, 26, 1215–1227.
Schonberg, T., Pianka, P., Hendler, T., Pasternak, O., & Assaf, Y. (2005). Characterization of displaced white matter by brain tumor by fMRI and DTI. NeuroImage, 30, 1100–1111, 2006.
Sinha, S., Bastin, M. E., Whittle, I. R., & Wardlaw, J. M. (2002). Diffusion tensor MR imaging of high-grade cerebral gliomas. American Journal of Neuroradiology, 23, 520–527.
Sorensen, A. G., Wu, O., Copen, W. A., Davis, T. L., Gonzalez, R. G., Koroshetz, W. J., et al. (1999). Human acute cerebral ischemia: detection of changes in water diffusion anisotropy by using MR imaging. Radiology, 212, 785–792.
Sotak, C. H. (2002). The role of diffusion tensor imaging in the evaluation of ischemic brain injury—a review. NMR in Biomedicine, 15, 561–569.
Szeszko, P. R., Ardekani, B. A., Ashtari, M., Malhotra, A. K., Robinson, D. G., Bilder, R. M., et al. (2005). White matter abnormalities in obsessive-compulsive disorder: a diffusion tensor imaging study. Archives of General Psychiatry, 67, 782–790.
Thomalla, G., Glauche, V., Koch, M. A., Beaulieu, C., Weiller, C., & Rother, J. (2004). Diffusion tensor imaging detects early Wallerian degeneration of the pyramidal tract after ischemic stroke. NeuroImage, 22, 1767–1774.
Tuch, D. S. (2004). Q-ball imaging. Magnetic Resonance in Medicine, 52, 1358–1372.
Tuch, D. S., Reese, T. G., Wiegell, M. R., Makris, N., Belliveau, J. W., & Wedeen, V. J. (2002). High angular resolution diffusion imaging reveals intravoxel white matter fiber heterogeneity. Magnetic Resonance in Medicine, 48, 577–582.
Tuch, D. S., Reese, T. G., Wiegell, M. R., & Wedeen, V. J. (2003). Diffusion MRI of complex neural architecture. Neuron, 40, 885–895.
Ulug, A. M., & van Zijl, P. C. (1999). Orientation-independent diffusion imaging without tensor diagonalization: anisotropy definitions based on physical attributes of the diffusion ellipsoid. Journal of Magnetic Resonance Imaging, 9, 804–813.
Werring, D. J., Clark, C. A., Barker, G. J., Thompson, A. J., & Miller, D. H. (1999). Diffusion tensor imaging of lesions and normal-appearing white matter in multiple sclerosis. Neurology, 52, 1626–1632.
Werring, D. J., Toosy, A. T., Clark, C. A., Parker, G. J., Barker, G. J., Miller, D. H., et al. (2000). Diffusion tensor imaging can detect and quantify corticospinal tract degeneration after stroke. Journal of Neurology, Neurosurgery and Psychiatry, 69, 269–272.
Westin, C. F., Maier, S. E., Mamata, H., Nabavi, A., Jolesz, F. A., & Kikinis, R. (2002). Processing and visualization for diffusion tensor MRI. Medical Image Analysis, 6, 93–108.
Wick, W., & Kuker, W. (2004). Brain edema in neurooncology: radiological assessment and management. Onkologie, 27, 261–266.
Witwer, B. P., Moftakhar, R., Hasan, K. M., Deshmukh, P., Haughton, V., Field, A., et al. (2002). Diffusion tensor imaging of white matter tracts in patients with cerebral neoplasm. Journal of Neurosurgery, 97, 568–575.
Yang, Q., Tress, B. M., Barber, P. A., Desmond, P. M., Darby, D. G., Gerraty, R. P., et al. (1999). Serial study of apparent diffusion coefficient and anisotropy in patients with acute stroke. Stroke, 30, 2382–2390.
Zelaya, F., Flood, N., Chalk, J. B., Wang, D., Doddrell, D. M., Strugnell, W., et al. (1999). An evaluation of the time dependence of the anisotropy of the water diffusion tensor in acute human ischemia. Magnetic Resonance Imaging, 17, 331–348.
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Assaf, Y., Pasternak, O. Diffusion Tensor Imaging (DTI)-based White Matter Mapping in Brain Research: A Review. J Mol Neurosci 34, 51–61 (2008). https://doi.org/10.1007/s12031-007-0029-0
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DOI: https://doi.org/10.1007/s12031-007-0029-0