Online full-text content begins with the 25th issue, and will expand with each month's new issues. Abstracts are online beginning with the 25th issue.

Each issue will be placed online approximately on the date it is mailed to subscribers, so the online site may be days or even weeks ahead of your receipt of a paper copy.

In addition, the table of contents of the upcoming issues will regularly be placed online as a future table of contents.

The Web site also provides access to information about the journal (such as Instructions to Authors, the Editorial Board, and subscription information and on-line subscription ordering), as well as access to other services.

The site is free and available to all on the Internet through the end of the trial period. Thereafter, access will be by institutional site license, which comes with all institutional subscriptions, or by personal subscription. Members will have certain enhanced features available to them.

We would appreciate comments, critiques, questions, or suggestions from you; these can be sent via the Feedback button found on all pages of the site. Feedback from readers will help us decide what new features would be most valuable for the site, and how well it is working for its readers.

The site is being produced in conjunction with Stanford University's HighWire Press, which also works with other medical/research journals, such as Science Magazine, the Journal of Biological Chemistry, and the Proceedings of the National Academy of Sciences. A list of online journals and URLs is available at:

http://highwire.stanford.edu